Naturally occurring dominant resistance mutations to HCV protease and polymerase inhibitors in treatment-naïve patients

Resistance mutations to HCV NS3 protease inhibitors in <1% of the viral quasispecies may still allow >1000-fold viral load reductions upon treatment, consistent with their reported reduced replicative fitness in vitro. Recently, however, an R155K protease mutation was reported as the dominant...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kuntzen, Thomas, Timm, Joerg, Berical, Andrew, Lennon, Niall, Berlin, Aaron M., Young, Sarah K., Lee, Bongshin, Heckerman, David, Carlson, Jonathan, Reyor, Laura L., Kleyman, Marianna, McMahon, Cory M., Birch, Christopher, Wiesch, Julian Schulze zur, Ledlie, Timothy, Koehrsen, Michael, Kodira, Chinnappa, Roberts, Andrew D., Lauer, Georg M., Rosen, Hugo R., Bihl, Florian, Cerny, Andreas, Spengler, Ulrich, Liu, Zhimin, Kim, Arthur Y., Xing, Yanming, Schneidewind, Arne, Madey, Margaret A., Fleckenstein, Jaquelyn F., Park, Vicki M., Galagan, James E., Nusbaum, Chad, Walker, Bruce D., Lake-Bakaar, Gerond V., Daar, Eric S., Jacobson, Ira M., Gomperts, Edward D., Edlin, Brian R., Donfield, Sharyne M., Chung, Raymond T., Talal, Andrew H., Marion, Tony, Birren, Bruce W., Henn, Matthew R., Allen, Todd M.
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: 2008
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645896/
https://ncbi.nlm.nih.gov/pubmed/19026009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22549
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2645896/
https://ncbi.nlm.nih.gov/pubmed/19026009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22549

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