Heritability and Genome-Wide Linkage in US and Australian Twins Identify Novel Genomic Regions Controlling Chromogranin A: Implications for Secretion and Blood Pressure

BACKGROUND: Chromogranin A (CHGA) triggers catecholamine secretory granule biogenesis, and its catestatin fragment inhibits catecholamine release. We approached catestatin heritability using twin pairs, coupled with genome-wide linkage, in a series of twin and sibling pairs from 2 continents. METHOD...

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Main Authors: O’Connor, Daniel T., Zhu, Gu, Rao, Fangwen, Taupenot, Laurent, Fung, Maple M., Das, Madhusudan, Mahata, Sushil K., Mahata, Manjula, Wang, Lei, Zhang, Kuixing, Greenwood, Tiffany A., Shih, Pei-an Betty, Cockburn, Myles G., Ziegler, Michael G., Stridsberg, Mats, Martin, Nicholas G., Whitfield, John B.
Formato: Artigo
Idioma:English
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654229/
https://ncbi.nlm.nih.gov/pubmed/18591442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.709105
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2654229/
https://ncbi.nlm.nih.gov/pubmed/18591442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.709105

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