Intracellular Activity of Antibiotics in a Model of Human THP-1 Macrophages Infected by a Staphylococcus aureus Small-Colony Variant Strain Isolated from a Cystic Fibrosis Patient: Pharmacodynamic Evaluation and Comparison with Isogenic Normal-Phenotype and Revertant Strains

Small-colony variant (SCV) strains of Staphylococcus aureus show reduced antibiotic susceptibility and intracellular persistence, potentially explaining therapeutic failures. The activities of oxacillin, fusidic acid, clindamycin, gentamicin, rifampin, vancomycin, linezolid, quinupristin-dalfopristi...

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Detalhes bibliográficos
Main Authors: Nguyen, Hoang Anh, Denis, Olivier, Vergison, Anne, Theunis, Anne, Tulkens, Paul M., Struelens, Marc J., Van Bambeke, Françoise
Formato: Artigo
Idioma:English
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663071/
https://ncbi.nlm.nih.gov/pubmed/19188393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01145-08
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2663071/
https://ncbi.nlm.nih.gov/pubmed/19188393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01145-08

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