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Common variants near MC4R are associated with fat mass, weight and risk of obesity

To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 × 10(−6)) mapped 188 kb downstream of MC4R (melanocort...

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Detalhes bibliográficos
Main Authors: Loos, Ruth J F, Lindgren, Cecilia M, Li, Shengxu, Wheeler, Eleanor, Zhao, Jing Hua, Prokopenko, Inga, Inouye, Michael, Freathy, Rachel M, Attwood, Antony P, Beckmann, Jacques S, Berndt, Sonja I, Bergmann, Sven, Bennett, Amanda J, Bingham, Sheila A, Bochud, Murielle, Brown, Morris, Cauchi, Stéphane, Connell, John M, Cooper, Cyrus, Smith, George Davey, Day, Ian, Dina, Christian, De, Subhajyoti, Dermitzakis, Emmanouil T, Doney, Alex S F, Elliott, Katherine S, Elliott, Paul, Evans, David M, Farooqi, I Sadaf, Froguel, Philippe, Ghori, Jilur, Groves, Christopher J, Gwilliam, Rhian, Hadley, David, Hall, Alistair S, Hattersley, Andrew T, Hebebrand, Johannes, Heid, Iris M, Herrera, Blanca, Hinney, Anke, Hunt, Sarah E, Jarvelin, Marjo-Riitta, Johnson, Toby, Jolley, Jennifer D M, Karpe, Fredrik, Keniry, Andrew, Khaw, Kay-Tee, Luben, Robert N, Mangino, Massimo, Marchini, Jonathan, McArdle, Wendy L, McGinnis, Ralph, Meyre, David, Munroe, Patricia B, Morris, Andrew D, Ness, Andrew R, Neville, Matthew J, Nica, Alexandra C, Ong, Ken K, O'Rahilly, Stephen, Owen, Katharine R, Palmer, Colin N A, Papadakis, Konstantinos, Potter, Simon, Pouta, Anneli, Qi, Lu, Randall, Joshua C, Rayner, Nigel W, Ring, Susan M, Sandhu, Manjinder S, Scherag, André, Sims, Matthew A, Song, Kijoung, Soranzo, Nicole, Speliotes, Elizabeth K, Syddall, Holly E, Teichmann, Sarah A, Timpson, Nicholas J, Tobias, Jonathan H, Uda, Manuela, Vogel, Carla I Ganz, Wallace, Chris, Waterworth, Dawn M, Weedon, Michael N, Willer, Cristen J, Wraight, Vicki L, Yuan, Xin, Zeggini, Eleftheria, Hirschhorn, Joel N, Strachan, David P, Ouwehand, Willem H, Caulfield, Mark J, Samani, Nilesh J, Frayling, Timothy M, Vollenweider, Peter, Waeber, Gerard, Mooser, Vincent, Deloukas, Panos, McCarthy, Mark I, Wareham, Nicholas J, Barroso, Inês, Jacobs, Kevin B, Chanock, Stephen J, Hayes, Richard B, Lamina, Claudia, Gieger, Christian, Illig, Thomas, Meitinger, Thomas, Wichmann, H-Erich, Kraft, Peter, Hankinson, Susan E, Hunter, David J, Hu, Frank B, Lyon, Helen N, Voight, Benjamin F, Ridderstrale, Martin, Groop, Leif, Scheet, Paul, Sanna, Serena, Abecasis, Goncalo R, Albai, Giuseppe, Nagaraja, Ramaiah, Schlessinger, David, Jackson, Anne U, Tuomilehto, Jaakko, Collins, Francis S, Boehnke, Michael, Mohlke, Karen L
Formato: Artigo
Idioma:English
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669167/
https://ncbi.nlm.nih.gov/pubmed/18454148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.140
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