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Dysregulation of glucocorticoid metabolism in murine obesity: comparable effects of leptin resistance and deficiency
In obese humans, metabolism of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and A-ring reduction (by 5α- and 5β-reductases) is dysregulated in a tissue specific manner. These changes have been recapitulated in leptin resistant obese Zucker rats but were not observed in high-...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
BioScientifica
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2674682/ https://ncbi.nlm.nih.gov/pubmed/19223399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JOE-09-0003 |
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