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Ras-Mitogen Activated Protein Kinase Signaling Promotes Trophectoderm Formation from Embryonic Stem Cells and Murine Embryos
In blastocyst chimeras, embryonic stem (ES) cells contribute to embryonic tissues but not extra-embryonic trophectoderm. Conditional activation of H-Ras61L in ES cells in vitro induces the trophectoderm marker Cdx2 and enables derivation of trophoblast stem (TS) cell lines that, when injected into b...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2690707/ https://ncbi.nlm.nih.gov/pubmed/18536715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.173 |
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