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Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
Aneuploidy, an incorrect chromosome number, is the leading cause of miscarriages and mental retardation in humans and is a hallmark of cancer. We examined the effects of aneuploidy on primary mouse cells by generating a series of cell lines that carry an extra copy of one of four mouse chromosomes....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701511/ https://ncbi.nlm.nih.gov/pubmed/18974345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1160058 |
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