Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma

BACKGROUND: Insulin-like growth factor (IGF)-I signalling stimulates proliferation, survival, and invasion in malignant mesothelioma and other tumour types. Studies have found that tumourigenesis is linked to dysregulation of cap-dependent protein translation. METHODS: The effect of IGF stimulation...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jacobson, B A, De, A, Kratzke, M G, Patel, M R, Jay-Dixon, J, Whitson, B A, Sadiq, A A, Bitterman, P B, Polunovsky, V A, Kratzke, R A
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Nature Publishing Group 2009
Pynciau:
Translational Therapeutics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720234/
https://ncbi.nlm.nih.gov/pubmed/19603014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605184
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Rhyngrwyd

https://ncbi.nlm.nih.gov/pmc/articles/PMC2720234/
https://ncbi.nlm.nih.gov/pubmed/19603014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605184

Eitemau Tebyg