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Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity

A recessive nonsense mutation in the zebrafish recombination activating gene 1 (rag1) gene results in defective V(D)J recombination; however, animals homozygous for this mutation (rag1(-/-)) are reportedly viable and fertile in standard, nonsterile aquarium conditions but display increased mortality...

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Detalhes bibliográficos
Main Authors: Jima, Dereje D., Shah, Radhika N., Orcutt, Timothy M., Joshi, Deepa, Law, J. McHugh, Litman, Gary W., Trede, Nikolaus S., Yoder, Jeffrey A.
Formato: Artigo
Idioma:English
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735268/
https://ncbi.nlm.nih.gov/pubmed/19200601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2008.12.021
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