The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history

Classical familial adenomatous polyposis (FAP) is a high-penetrance autosomal dominant disease that predisposes to hundreds or thousands of colorectal adenomas and carcinoma and that results from truncating mutations in the APC gene. A variant of FAP is attenuated adenomatous polyposis coli, which r...

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Detalhes bibliográficos
Main Authors: Frayling, Ian M., Beck, Nicholas E., Ilyas, Mohammad, Dove-Edwin, Isis, Goodman, Peter, Pack, Kevin, Bell, Jennifer A., Williams, Christopher B., Hodgson, Shirley V., Thomas, Huw J. W., Talbot, Ian C., Bodmer, Walter F., Tomlinson, Ian P. M.
Formato: Artigo
Idioma:en
Publicado em: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC27962/
https://ncbi.nlm.nih.gov/pubmed/9724771
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https://ncbi.nlm.nih.gov/pmc/articles/PMC27962/
https://ncbi.nlm.nih.gov/pubmed/9724771

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