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Evidence for Proteotoxicity in β Cells in Type 2 Diabetes : Toxic Islet Amyloid Polypeptide Oligomers Form Intracellularly in the Secretory Pathway
The islet in type 2 diabetes mellitus (T2DM) is characterized by a deficit in β cells and islet amyloid derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin by β cells. It is increasingly appreciated that the toxic form of amyloidogenic proteins is not amyloid but small...
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| Format: | Article |
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| Idioma: | en |
| Publicat: |
American Society for Investigative Pathology
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2808091/ https://ncbi.nlm.nih.gov/pubmed/20042670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090532 |
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