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Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.

The rapid clearance of circulating liposomes from the bloodstream, coupled with their high uptake by liver and spleen, has thus far been an obstacle to any attempts at targeting to tumors. We have assessed the impact of liposome composition on their clearance from the circulation in normal and tumor...

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Detalhes bibliográficos
Main Authors:	Gabizon, A, Papahadjopoulos, D, Stern, M D, Silverman, H S, Houser, S R, Josephson, R A, Capogrossi, M C, Nichols, C G, Lederer, W J, Lakatta, E G, Hinoda, Y, Neumaier, M, Hefta, S A, Drzeniek, Z, Wagener, C, Shively, L, Hefta, L J, Shively, J E, Paxton, R J, Yanagisawa, M, Inoue, A, Ishikawa, T, Kasuya, Y, Kimura, S, Kumagaye, S, Nakajima, K, Watanabe, T X, Sakakibara, S, Goto, K, Matsuda, Z, Chou, M J, Matsuda, M, Huang, J H, Chen, Y M, Redfield, R, Mayer, K, Essex, M, Lee, T H, Nagy, L E, Diamond, I, Gordon, A, Mack, D H, Sninsky, J J, Goodman, S D, Scocca, J J, Snapper, S B, Lugosi, L, Jekkel, A, Melton, R E, Kieser, T, Bloom, B R, Jacobs, W R, Ratner, N, Hong, D M, Lieberman, M A, Bunge, R P, Glaser, L, Muller, D, Turnbull, J, Baudry, M, Lynch, G, Hashimoto, Y, King, M M, Soderling, T R, Konishi, M, Akutagawa, E, Kennedy, T E, Gawinowicz, M A, Barzilai, A, Kandel, E R, Sweatt, J D, Ueda, H, Harada, H, Nozaki, M, Katada, T, Ui, M, Satoh, M, Takagi, H, Alho, H, Fremeau, R T, Tiedge, H, Wilcox, J, Bovolin, P, Brosius, J, Roberts, J L, Costa, E, Kinnamon, S C, Dionne, V E, Beam, K G, Coulter, H D, Canlon, B, Brundin, L, Flock, A, DuBose, R F, Dykhuizen, D E, Hartl, D L, Dehmelt, Hans, Mittleman, Richard, Liu, Yuan, Pohlentz, G, Klein, D, Schwarzmann, G, Schmitz, D, Sandhoff, K, Tsai, S F, Bishop, D F, Desnick, R J, Dogbo, Odette, Laferriére, André, D'Harlingue, Alain, Camara, Bilal, Carey, M F, Singh, K, Roberts, J D, Kunkel, T A, Zacharias, W, Jaworski, A, Larson, J E, Wells, R D, Bauer, C E, Marrs, B L, Agrawal, S, Goodchild, J, Civeira, M P, Thornton, A H, Sarin, P S, Zamecnik, P C, Ichimura, T, Isobe, T, Okuyama, T, Takahashi, N, Araki, K, Kuwano, R, Takahashi, Y, Giuliano, G, Pichersky, E, Malik, V S, Timko, M P, Scolnik, P A, Cashmore, A R, Jentoft, J E, Smith, L M, Fu, X D, Johnson, M, Leis, J, Chiu, C P, Moulds, C, Coffman, R L, Rennick, D, Lee, F, Solish, S B, Picado-Leonard, J, Morel, Y, Kuhn, R W, Mohandas, T K, Hanukoglu, I, Miller, W L, Hardy, S J, Holmgren, J, Johansson, S, Sanchez, J, Hirst, T R, Hendriks, W, Mulders, J W, Bibby, M A, Slingsby, C, Bloemendal, H, de Jong, W W, Barton, M C, Shapiro, D J, Seiki, M, Inoue, J, Hidaka, M, Yoshida, M, Nutt, R F, Brady, S F, Darke, P L, Ciccarone, T M, Colton, C D, Nutt, E M, Rodkey, J A, Bennett, C D, Waxman, L H, Sigal, I S, Yarfitz, S, Provost, N M, Hurley, J B, Harper, J W, Vallee, B L, Srivastava, A K, Schlessinger, D, Roland, K L, Liu, C G, Turnbough, C L, Ballou, L M, Siegmann, M, Thomas, G, Cotecchia, S, Schwinn, D A, Randall, R R, Lefkowitz, R J, Caron, M G, Kobilka, B K, Joseph, L J, Le Beau, M M, Jamieson, G A, Acharya, S, Shows, T B, Rowley, J D, Sukhatme, V P, McCance, D J, Kopan, R, Fuchs, E, Laimins, L A, Groziak, M P, Bhat, B, Leonard, N J, Tsai-Pflugfelder, M, Liu, L F, Liu, A A, Tewey, K M, Whang-Peng, J, Knutsen, T, Huebner, K, Croce, C M, Wang, J C, Charbonneau, H, Tonks, N K, Walsh, K A, Fischer, E H
Formato:	Artigo
Idioma:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Publicado em:	1988
Assuntos:	Research Article Physical Sciences: Physics Biological Sciences: Biochemistry
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC282096/ https://ncbi.nlm.nih.gov/pubmed/3413128 https://ncbi.nlm.nih.gov/pmc/articles/PMC282097/ https://ncbi.nlm.nih.gov/pubmed/3413129 https://ncbi.nlm.nih.gov/pmc/articles/PMC282098/ https://ncbi.nlm.nih.gov/pubmed/2457922 https://ncbi.nlm.nih.gov/pmc/articles/PMC282099/ https://ncbi.nlm.nih.gov/pubmed/3045827 https://ncbi.nlm.nih.gov/pmc/articles/PMC282100/ https://ncbi.nlm.nih.gov/pubmed/2842797 https://ncbi.nlm.nih.gov/pmc/articles/PMC282101/ https://ncbi.nlm.nih.gov/pubmed/2842798 https://ncbi.nlm.nih.gov/pmc/articles/PMC282102/ https://ncbi.nlm.nih.gov/pubmed/2457923 https://ncbi.nlm.nih.gov/pmc/articles/PMC282103/ https://ncbi.nlm.nih.gov/pubmed/3137581 https://ncbi.nlm.nih.gov/pmc/articles/PMC282104/ https://ncbi.nlm.nih.gov/pubmed/2842799 https://ncbi.nlm.nih.gov/pmc/articles/PMC282105/ https://ncbi.nlm.nih.gov/pubmed/3413130 https://ncbi.nlm.nih.gov/pmc/articles/PMC282106/ https://ncbi.nlm.nih.gov/pubmed/3166141 https://ncbi.nlm.nih.gov/pmc/articles/PMC282107/ https://ncbi.nlm.nih.gov/pubmed/2842800 https://ncbi.nlm.nih.gov/pmc/articles/PMC282108/ https://ncbi.nlm.nih.gov/pubmed/3413131 https://ncbi.nlm.nih.gov/pmc/articles/PMC282109/ https://ncbi.nlm.nih.gov/pubmed/3413132 https://ncbi.nlm.nih.gov/pmc/articles/PMC282110/ https://ncbi.nlm.nih.gov/pubmed/2842801 https://ncbi.nlm.nih.gov/pmc/articles/PMC282111/ https://ncbi.nlm.nih.gov/pubmed/3413133 https://ncbi.nlm.nih.gov/pmc/articles/PMC282112/ https://ncbi.nlm.nih.gov/pubmed/2457924 https://ncbi.nlm.nih.gov/pmc/articles/PMC282113/ https://ncbi.nlm.nih.gov/pubmed/3413134 https://ncbi.nlm.nih.gov/pmc/articles/PMC282114/ https://ncbi.nlm.nih.gov/pubmed/3413135 https://ncbi.nlm.nih.gov/pmc/articles/PMC282115/ https://ncbi.nlm.nih.gov/pubmed/3045828 https://ncbi.nlm.nih.gov/pmc/articles/PMC282119/ https://ncbi.nlm.nih.gov/pubmed/16578834 https://ncbi.nlm.nih.gov/pmc/articles/PMC282120/ https://ncbi.nlm.nih.gov/pubmed/3140234 https://ncbi.nlm.nih.gov/pmc/articles/PMC282121/ https://ncbi.nlm.nih.gov/pubmed/3174619 https://ncbi.nlm.nih.gov/pmc/articles/PMC282122/ https://ncbi.nlm.nih.gov/pubmed/16578835 https://ncbi.nlm.nih.gov/pmc/articles/PMC282123/ https://ncbi.nlm.nih.gov/pubmed/2845394 https://ncbi.nlm.nih.gov/pmc/articles/PMC282124/ https://ncbi.nlm.nih.gov/pubmed/3174620 https://ncbi.nlm.nih.gov/pmc/articles/PMC282125/ https://ncbi.nlm.nih.gov/pubmed/3050986 https://ncbi.nlm.nih.gov/pmc/articles/PMC282126/ https://ncbi.nlm.nih.gov/pubmed/3174621 https://ncbi.nlm.nih.gov/pmc/articles/PMC282127/ https://ncbi.nlm.nih.gov/pubmed/3174622 https://ncbi.nlm.nih.gov/pmc/articles/PMC282128/ https://ncbi.nlm.nih.gov/pubmed/2902623 https://ncbi.nlm.nih.gov/pmc/articles/PMC282129/ https://ncbi.nlm.nih.gov/pubmed/2902624 https://ncbi.nlm.nih.gov/pmc/articles/PMC282130/ https://ncbi.nlm.nih.gov/pubmed/2845395 https://ncbi.nlm.nih.gov/pmc/articles/PMC282131/ https://ncbi.nlm.nih.gov/pubmed/3262872 https://ncbi.nlm.nih.gov/pmc/articles/PMC282132/ https://ncbi.nlm.nih.gov/pubmed/2845396 https://ncbi.nlm.nih.gov/pmc/articles/PMC282133/ https://ncbi.nlm.nih.gov/pubmed/3050987 https://ncbi.nlm.nih.gov/pmc/articles/PMC282134/ https://ncbi.nlm.nih.gov/pubmed/3174623 https://ncbi.nlm.nih.gov/pmc/articles/PMC282135/ https://ncbi.nlm.nih.gov/pubmed/3174624 https://ncbi.nlm.nih.gov/pmc/articles/PMC282136/ https://ncbi.nlm.nih.gov/pubmed/3174625 https://ncbi.nlm.nih.gov/pmc/articles/PMC282137/ https://ncbi.nlm.nih.gov/pubmed/3050988 https://ncbi.nlm.nih.gov/pmc/articles/PMC282138/ https://ncbi.nlm.nih.gov/pubmed/3140235 https://ncbi.nlm.nih.gov/pmc/articles/PMC282139/ https://ncbi.nlm.nih.gov/pubmed/2459697 https://ncbi.nlm.nih.gov/pmc/articles/PMC282140/ https://ncbi.nlm.nih.gov/pubmed/3050989 https://ncbi.nlm.nih.gov/pmc/articles/PMC282141/ https://ncbi.nlm.nih.gov/pubmed/2459698 https://ncbi.nlm.nih.gov/pmc/articles/PMC282142/ https://ncbi.nlm.nih.gov/pubmed/2845397 https://ncbi.nlm.nih.gov/pmc/articles/PMC282143/ https://ncbi.nlm.nih.gov/pubmed/2845398 https://ncbi.nlm.nih.gov/pmc/articles/PMC282144/ https://ncbi.nlm.nih.gov/pubmed/3140236 https://ncbi.nlm.nih.gov/pmc/articles/PMC282145/ https://ncbi.nlm.nih.gov/pubmed/2459699 https://ncbi.nlm.nih.gov/pmc/articles/PMC282146/ https://ncbi.nlm.nih.gov/pubmed/3174626 https://ncbi.nlm.nih.gov/pmc/articles/PMC282147/ https://ncbi.nlm.nih.gov/pubmed/2845399 https://ncbi.nlm.nih.gov/pmc/articles/PMC282148/ https://ncbi.nlm.nih.gov/pubmed/2845400
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Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.

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