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Overcoming Amino-Nogo-induced Inhibition of Cell Spreading and Neurite Outgrowth by 12-O-Tetradecanoylphorbol-13-acetate-type Tumor Promoters
The N-terminal domain of NogoA, called amino-Nogo, inhibits axonal outgrowth and cell spreading via a largely unknown mechanism. In the present study, we show that amino-Nogo decreases Rac1 activity and inhibits fibroblast spreading. 12-O-Tetradecanoylphorbol-13-acetate-type tumor promoters, such as...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2825438/ https://ncbi.nlm.nih.gov/pubmed/20018888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.071548 |
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