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Novel Hydroxysteroid (17β) Dehydrogenase 1 Inhibitors Reverse Estrogen-Induced Endometrial Hyperplasia in Transgenic Mice
Local estrogen production plays a key role in proliferative endometrial disorders, such as endometrial hyperplasia and cancer. Hydroxysteroid (17β) dehydrogenase 1 (HSD17B1) is an enzyme that catalyzes with high efficiency the conversion of weakly active estrone into highly potent estradiol. Here we...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
American Society for Investigative Pathology
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2832163/ https://ncbi.nlm.nih.gov/pubmed/20093485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090325 |
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