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A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes

In this pilot study, we used primary human acute myeloid leukemia (AML) cell genomes as templates for exonic PCR amplification, followed by high-throughput resequencing, analyzing ≈7 million base pairs of DNA from 140 AML samples and 48 controls. We identified six previously described, and seven pre...

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Autori principali: Ley, Timothy J., Minx, Patrick J., Walter, Matthew J., Ries, Rhonda E., Sun, Hui, McLellan, Michael, DiPersio, John F., Link, Daniel C., Tomasson, Michael H., Graubert, Timothy A., McLeod, Howard, Khoury, Hanna, Watson, Mark, Shannon, William, Trinkaus, Kathryn, Heath, Sharon, Vardiman, James W., Caligiuri, Michael A., Bloomfield, Clara D., Milbrandt, Jeffrey D., Mardis, Elaine R., Wilson, Richard K.
Natura: Articolo
Lingua:en
Pubblicazione: National Academy of Sciences 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC283582/
https://ncbi.nlm.nih.gov/pubmed/14614138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2335924100
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