Residues 190–210 of human topoisomerase I are required for enzyme activity in vivo but not in vitro

DNA-topoisomerase I (topo I) unwinds the DNA- double helix by cutting one strand and allowing rotation of the other. In vitro, this function does not require the N-terminal domain of the enzyme, which is believed to regulate cellular properties. To assess this role, we studied the cellular distribut...

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Main Authors: Christensen, Morten O., Barthelmes, Hans U., Boege, Fritz, Mielke, Christian, Bai, Longchuan, Merchant, Juanita L., Seetharaman, Mahadevan, Williams, Caroline, Cramer, Christopher J., Musier-Forsyth, Karin, Ono, Katsuki, Kusano, Osamu, Shimotakahara, Sakurako, Shimizu, Mitsuhiro, Yamazaki, Toshimasa, Shindo, Heisaburo, Ivakine, Evgueni, Spasov, Krasimir, Frendewey, David, Nazar, Ross N., Lee, Yun Sok, Lee, Hyoung Ho, Park, Jiyoung, Yoo, Eung Jae, Glackin, Carlotta A., Choi, Young Il, Jeon, Sung Ho, Seong, Rho Hyun, Park, Sang Dai, Kim, Jae Bum, Hanaoka, Mitsumasa, Kanamaru, Kengo, Takahashi, Hideo, Tanaka, Kan, Kühne, Christian, Tjörnhammar, Marie-Louise, Pongor, Sándor, Banks, Lawrence, Simoncsits, András, Pan, Yongping, MacKerell, Alexander D., Kanevsky, Igor, Vasilenko, Natalya, Dumay-Odelot, Hélène, Fossé, Philippe, Loenen, Wil A. M., Long, Katherine S., Porse, Bo T., Kojima, Naoshi, Inoue, Kaori, Nakajima-Shibata, Rina, Kawahara, Shun-ichi, Ohtsuka, Eiko, Wang, Xiaowei, Seed, Brian, Blondal, Thorarinn, Waage, Benedikt G., Smarason, Sigurdur V., Jonsson, Frosti, Fjalldal, Sigridur B., Stefansson, Kari, Gulcher, Jeffery, Smith, Albert V., Maisels, M. Jeffrey, Pathak, Ambadas, Nelson, Nicholas M., Nathan, David G., Smith, Clement A., Dastur, Darab K., Manghani, Daya K., Raghavendran, K. V., Arnaud, Claude D., Tsao, Hang S., Littledike, Travis, Kramp, Ronald A., Lassiter, William E., Gottschalk, Carl W., Cunningham, J. N., Carter, N. W., Rector, F. C., Seldin, D. W., Burka, Edward R., Kokko, Juha P., Burg, Maurice B., Orloff, Jack, Buentig, Wolf E., Earley, Laurence E., Rudman, Daniel, DeRubertis, Frederick R., Michelis, Michael F., Beck, Nama, Field, James B., Davis, Bernard B., Gill, John R., Casper, Alfred G. T., Bailie, Michael D., Rector, Floyd C., Seldin, Donald W., Hsia, Y. Edward, Scully, Katherine J., Rosenberg, Leon E., Salzman, Edwin W., Levine, Linda, Streeten, David H. P., Dalakos, Theodore G., Fellerman, Herbert, Duane, William C., Frerichs, Roger, Levitt, Michael D., Kreisberg, Robert A., Owen, W. Crawford, Siegal, Alan M., Weil, John V., Byrne-Quinn, Edward, Sodal, Ingvar E., Filley, Giles F., Grover, Robert F., Hsieh, Hsin-Soon, Jaffé, Ernst R., Scholnick, Perry, Marver, Harvey S., Schmid, Rudi, Goldstein, Marc B., Gennari, F. John, Schwartz, William B., Kumar, Raj, Joison, Julio, Gilmour, David P., Molokhia, Farouk A., Pegg, C. A. S., Hood, William B., Pachman, Lauren M., Esterly, Nancy B., Peterson, Raymond D. A., Sebastian, Anthony, McSherry, Elisabeth, Morris, R. Curtis, Zimmerman, Theodore S., Ratnoff, Oscar D., Powell, Arnold E., Littell, Arthur S., Jones, Don P., Sosa, Freddy R., Shartsis, Jack, Shah, Praful T., Skromak, Eileen, Beher, William T., Herman, Jerome H., Bradley, John, Ziff, Morris, Smiley, J. Donald, Douglas, Kathryn S., Perkins, Herbert A., Cochrum, Kent, Kountz, Samuel L., Marcus, Robert L., Townes, Alexander S., Bank, Norman, Yarger, William E., Aynedjian, Hagop S., Bourgoignie, Jacques, Klahr, Saulo, Bricker, Neal S.
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Publicado em: Oxford University Press 2003
Assuntos:
Articles
Errata
NAR Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC291868/
https://ncbi.nlm.nih.gov/pubmed/14654701
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https://ncbi.nlm.nih.gov/pubmed/14654702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg929
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https://ncbi.nlm.nih.gov/pubmed/14654706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg930
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https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg931
https://ncbi.nlm.nih.gov/pmc/articles/PMC291872/
https://ncbi.nlm.nih.gov/pubmed/14654686
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https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg934
https://ncbi.nlm.nih.gov/pmc/articles/PMC291874/
https://ncbi.nlm.nih.gov/pubmed/14654684
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https://ncbi.nlm.nih.gov/pubmed/4395909
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https://ncbi.nlm.nih.gov/pmc/articles/PMC291900/
https://ncbi.nlm.nih.gov/pubmed/5101292
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https://ncbi.nlm.nih.gov/pubmed/5101297
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https://ncbi.nlm.nih.gov/pubmed/5543879
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https://ncbi.nlm.nih.gov/pubmed/5540164
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https://ncbi.nlm.nih.gov/pmc/articles/PMC291921/
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https://ncbi.nlm.nih.gov/pmc/articles/PMC291922/
https://ncbi.nlm.nih.gov/pubmed/4992991
https://ncbi.nlm.nih.gov/pmc/articles/PMC291923/
https://ncbi.nlm.nih.gov/pubmed/5540167
https://ncbi.nlm.nih.gov/pmc/articles/PMC291924/
https://ncbi.nlm.nih.gov/pubmed/5540168
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https://ncbi.nlm.nih.gov/pmc/articles/PMC291868/
https://ncbi.nlm.nih.gov/pubmed/14654701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg927
https://ncbi.nlm.nih.gov/pmc/articles/PMC291869/
https://ncbi.nlm.nih.gov/pubmed/14654702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg929
https://ncbi.nlm.nih.gov/pmc/articles/PMC291870/
https://ncbi.nlm.nih.gov/pubmed/14654706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg930
https://ncbi.nlm.nih.gov/pmc/articles/PMC291871/
https://ncbi.nlm.nih.gov/pubmed/14654695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg931
https://ncbi.nlm.nih.gov/pmc/articles/PMC291872/
https://ncbi.nlm.nih.gov/pubmed/14654686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg932
https://ncbi.nlm.nih.gov/pmc/articles/PMC291873/
https://ncbi.nlm.nih.gov/pubmed/14654692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg934
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https://ncbi.nlm.nih.gov/pmc/articles/PMC291875/
https://ncbi.nlm.nih.gov/pubmed/14654698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg937
https://ncbi.nlm.nih.gov/pmc/articles/PMC291876/
https://ncbi.nlm.nih.gov/pubmed/14654688
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https://ncbi.nlm.nih.gov/pmc/articles/PMC291878/
https://ncbi.nlm.nih.gov/pubmed/14654681
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https://ncbi.nlm.nih.gov/pubmed/14654708
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https://ncbi.nlm.nih.gov/pmc/articles/PMC291900/
https://ncbi.nlm.nih.gov/pubmed/5101292
https://ncbi.nlm.nih.gov/pmc/articles/PMC291901/
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https://ncbi.nlm.nih.gov/pubmed/4992991
https://ncbi.nlm.nih.gov/pmc/articles/PMC291923/
https://ncbi.nlm.nih.gov/pubmed/5540167
https://ncbi.nlm.nih.gov/pmc/articles/PMC291924/
https://ncbi.nlm.nih.gov/pubmed/5540168

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