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Deficiency in phosphorylase phosphatase activity despite elevated protein phosphatase type-1 catalytic subunit in skeletal muscle from insulin-resistant subjects.

Glycogen synthase is activated by protein phosphatase type-1 (PP-1). The spontaneous PP-1 activity accounts for only a small fraction of total PP-1 activity, which can be exposed by trypsin digestion of inhibitor proteins in the presence of Mn2+. We determined total PP-1 activity in muscle biopsies...

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Main Authors:	Nyomba, B L, Brautigan, D L, Schlender, K K, Wang, W, Bogardus, C, Mott, D M, Turki, J, Pak, J, Green, S A, Martin, R J, Liggett, S B, Block, N E, Menick, D R, Robinson, K A, Buse, M G, Varro, A, Voronina, S, Dockray, G J, Wood, P A, Hrushesky, W J, Zhang, R, Alper, S L, Thorens, B, Verkman, A S, Chen, E H, Johnson, E E, Vetter, S M, Mitchell, B S, Chen, P Y, Sanders, P W, Kroll, M H, Harris, T S, Moake, J L, Handin, R I, Schafer, A I, Feng, L, Xia, Y, Garcia, G E, Hwang, D, Wilson, C B, AyanlarBatuman, O, Ferrero, A P, Diaz, A, Jimenez, S A, Gaudin, C, Ishikawa, Y, Wight, D C, Mahdavi, V, Nadal-Ginard, B, Wagner, T E, Vatner, D E, Homcy, C J, Black, F M, Packer, S E, Parker, T G, Michael, L H, Roberts, R, Schwartz, R J, Schneider, M D, Fitzgerald, D J, Hanson, M, FitzGerald, G A, Morin, C L, Schlaepfer, I R, Eckel, R H, Herrmann, M A, Hay, I D, Bartelt, D H, Ritland, S R, Dahl, R J, Grant, C S, Jenkins, R B, Trial, J, Birdsall, H H, Hallum, J A, Crane, M L, Rodriguez-Barradas, M C, de Jong, A L, Krishnan, B, Lacke, C E, Figdor, C G, Rossen, R D, Parkos, C A, Delp, C, Arnaout, M A, Madara, J L, Baronciani, L, Beutler, E, Blume, S W, Snyder, R C, Ray, R, Thomas, S, Koller, C A, Miller, D M, Wang, C, Chao, L, Chao, J, Waldenström, A, Martinussen, H J, Gerdin, B, Hällgren, R, Welsh, N, Bendtzen, K, Welsh, M, Sztalryd, C, Azhar, S, Reaven, G M, Fiorelli, V, Gendelman, R, Samaniego, F, Markham, P D, Ensoli, B, Margulies, K B, Perrella, M A, McKinley, L J, Burnett, J C, Rizzo, W B, Craft, D A, Coyle, A J, Ackerman, S J, Burch, R, Proud, D, Irvin, C G, Radovick, S, Ticknor, C M, Nakayama, Y, Notides, A C, Rahman, A, Weintraub, B D, Cutler, G B, Wondisford, F E, Schrier, R D, Freeman, W R, Wiley, C A, McCutchan, J A, Quyyumi, A A, Dakak, N, Andrews, N P, Husain, S, Arora, S, Gilligan, D M, Panza, J A, Cannon, R O, Unemori, E N, Hibbs, M S, Amento, E P, Díaz-González, F, González-Alvaro, I, Campanero, M R, Mollinedo, F, del Pozo, M A, Muñoz, C, Pivel, J P, Sánchez-Madrid, F, Cooke, J P, Rossitch, E, Andon, N A, Loscalzo, J, Dzau, V J, Allain, J P, Dailey, S H, Laurian, Y, Vallari, D S, Rafowicz, A, Desai, S M, Devare, S G, Huang, D F, Siminovitch, K A, Liu, X Y, Olee, T, Olsen, N J, Berry, C, Carson, D A, Chen, P P, de Munk, G A, Groeneveld, E, Rijken, D C, Warshawsky, I, Bu, G, Mast, A, Saffitz, J E, Broze, G J, Schwartz, A L, Watzke, H H, Wallmark, A, Hamaguchi, N, Giardina, P, Stafford, D W, High, K A, Bullard, D C, Qin, L, Lorenzo, I, Quinlin, W M, Doyle, N A, Bosse, R, Vestweber, D, Doerschuk, C M, Beaudet, A L, Marcus, A J, Safier, L B, Hajjar, K A, Ullman, H L, Islam, N, Broekman, M J, Eiroa, A M, Fant, M E, Warren, R S, Yuan, H, Matli, M R, Gillett, N A, Ferrara, N, Moe, O W, Miller, R T, Horie, S, Cano, A, Preisig, P A, Alpern, R J, Tuder, R M, Flook, B E, Voelkel, N F, Steers, W D, Kolbeck, S, Creedon, D, Tuttle, J B, Hovnanian, A, Duquesnoy, P, Amselem, S, Blanchet-Bardon, C, Lathrop, M, Dubertret, L, Goossens, M, Hamamori, Y, Samal, B, Tian, J, Kedes, L, Hardman, D A, Pullinger, C R, Hamilton, R L, Kane, J P, Malloy, M J, Beltinger, C, Saragovi, H U, Smith, R M, LeSauteur, L, Shah, N, DeDionisio, L, Christensen, L, Raible, A, Jarett, L, Gewirtz, A M
Formato:	Artigo
Idioma:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Publicado em:	1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC295665/ https://ncbi.nlm.nih.gov/pubmed/1658044 https://ncbi.nlm.nih.gov/pmc/articles/PMC295666/ https://ncbi.nlm.nih.gov/pubmed/7706471 https://ncbi.nlm.nih.gov/pmc/articles/PMC295667/ https://ncbi.nlm.nih.gov/pubmed/1939643 https://ncbi.nlm.nih.gov/pmc/articles/PMC295668/ https://ncbi.nlm.nih.gov/pubmed/7706472 https://ncbi.nlm.nih.gov/pmc/articles/PMC295669/ https://ncbi.nlm.nih.gov/pubmed/7706473 https://ncbi.nlm.nih.gov/pmc/articles/PMC295670/ https://ncbi.nlm.nih.gov/pubmed/1939644 https://ncbi.nlm.nih.gov/pmc/articles/PMC295671/ https://ncbi.nlm.nih.gov/pubmed/7706474 https://ncbi.nlm.nih.gov/pmc/articles/PMC295672/ https://ncbi.nlm.nih.gov/pubmed/1658045 https://ncbi.nlm.nih.gov/pmc/articles/PMC295673/ https://ncbi.nlm.nih.gov/pubmed/1939645 https://ncbi.nlm.nih.gov/pmc/articles/PMC295674/ https://ncbi.nlm.nih.gov/pubmed/7706475 https://ncbi.nlm.nih.gov/pmc/articles/PMC295675/ https://ncbi.nlm.nih.gov/pubmed/1939646 https://ncbi.nlm.nih.gov/pmc/articles/PMC295676/ https://ncbi.nlm.nih.gov/pubmed/7706476 https://ncbi.nlm.nih.gov/pmc/articles/PMC295677/ https://ncbi.nlm.nih.gov/pubmed/1834699 https://ncbi.nlm.nih.gov/pmc/articles/PMC295678/ https://ncbi.nlm.nih.gov/pubmed/1939647 https://ncbi.nlm.nih.gov/pmc/articles/PMC295679/ https://ncbi.nlm.nih.gov/pubmed/7706477 https://ncbi.nlm.nih.gov/pmc/articles/PMC295680/ https://ncbi.nlm.nih.gov/pubmed/1939648 https://ncbi.nlm.nih.gov/pmc/articles/PMC295681/ https://ncbi.nlm.nih.gov/pubmed/7706478 https://ncbi.nlm.nih.gov/pmc/articles/PMC295682/ https://ncbi.nlm.nih.gov/pubmed/1682344 https://ncbi.nlm.nih.gov/pmc/articles/PMC295683/ https://ncbi.nlm.nih.gov/pubmed/7706479 https://ncbi.nlm.nih.gov/pmc/articles/PMC295684/ https://ncbi.nlm.nih.gov/pubmed/1834700 https://ncbi.nlm.nih.gov/pmc/articles/PMC295685/ https://ncbi.nlm.nih.gov/pubmed/7535795 https://ncbi.nlm.nih.gov/pmc/articles/PMC295686/ https://ncbi.nlm.nih.gov/pubmed/1939649 https://ncbi.nlm.nih.gov/pmc/articles/PMC295687/ https://ncbi.nlm.nih.gov/pubmed/7706480 https://ncbi.nlm.nih.gov/pmc/articles/PMC295688/ https://ncbi.nlm.nih.gov/pubmed/1658046 https://ncbi.nlm.nih.gov/pmc/articles/PMC295689/ https://ncbi.nlm.nih.gov/pubmed/7535796 https://ncbi.nlm.nih.gov/pmc/articles/PMC295690/ https://ncbi.nlm.nih.gov/pubmed/1658047 https://ncbi.nlm.nih.gov/pmc/articles/PMC295691/ https://ncbi.nlm.nih.gov/pubmed/1939650 https://ncbi.nlm.nih.gov/pmc/articles/PMC295692/ https://ncbi.nlm.nih.gov/pubmed/7706481 https://ncbi.nlm.nih.gov/pmc/articles/PMC295693/ https://ncbi.nlm.nih.gov/pubmed/1939651 https://ncbi.nlm.nih.gov/pmc/articles/PMC295694/ https://ncbi.nlm.nih.gov/pubmed/7706482 https://ncbi.nlm.nih.gov/pmc/articles/PMC295695/ https://ncbi.nlm.nih.gov/pubmed/7706483 https://ncbi.nlm.nih.gov/pmc/articles/PMC295696/ https://ncbi.nlm.nih.gov/pubmed/1658048 https://ncbi.nlm.nih.gov/pmc/articles/PMC295697/ https://ncbi.nlm.nih.gov/pubmed/7535797 https://ncbi.nlm.nih.gov/pmc/articles/PMC295698/ https://ncbi.nlm.nih.gov/pubmed/1719029 https://ncbi.nlm.nih.gov/pmc/articles/PMC295699/ https://ncbi.nlm.nih.gov/pubmed/1939652 https://ncbi.nlm.nih.gov/pmc/articles/PMC295700/ https://ncbi.nlm.nih.gov/pubmed/7706484 https://ncbi.nlm.nih.gov/pmc/articles/PMC295701/ https://ncbi.nlm.nih.gov/pubmed/1658049 https://ncbi.nlm.nih.gov/pmc/articles/PMC295702/ https://ncbi.nlm.nih.gov/pubmed/7706485 https://ncbi.nlm.nih.gov/pmc/articles/PMC295703/ https://ncbi.nlm.nih.gov/pubmed/1939653 https://ncbi.nlm.nih.gov/pmc/articles/PMC295704/ https://ncbi.nlm.nih.gov/pubmed/7535798 https://ncbi.nlm.nih.gov/pmc/articles/PMC295705/ https://ncbi.nlm.nih.gov/pubmed/1939654 https://ncbi.nlm.nih.gov/pmc/articles/PMC295706/ https://ncbi.nlm.nih.gov/pubmed/1939655 https://ncbi.nlm.nih.gov/pmc/articles/PMC295707/ https://ncbi.nlm.nih.gov/pubmed/7535799 https://ncbi.nlm.nih.gov/pmc/articles/PMC295708/ https://ncbi.nlm.nih.gov/pubmed/1658050 https://ncbi.nlm.nih.gov/pmc/articles/PMC295709/ https://ncbi.nlm.nih.gov/pubmed/7706486 https://ncbi.nlm.nih.gov/pmc/articles/PMC295710/ https://ncbi.nlm.nih.gov/pubmed/1939656 https://ncbi.nlm.nih.gov/pmc/articles/PMC295711/ https://ncbi.nlm.nih.gov/pubmed/1658051 https://ncbi.nlm.nih.gov/pmc/articles/PMC295712/ https://ncbi.nlm.nih.gov/pubmed/7706487 https://ncbi.nlm.nih.gov/pmc/articles/PMC295713/ https://ncbi.nlm.nih.gov/pubmed/1939657 https://ncbi.nlm.nih.gov/pmc/articles/PMC295714/ https://ncbi.nlm.nih.gov/pubmed/7706488
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Deficiency in phosphorylase phosphatase activity despite elevated protein phosphatase type-1 catalytic subunit in skeletal muscle from insulin-resistant subjects.

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