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RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis
RapGEF2 is one of many guanine nucleotide exchange factors (GEFs) that specifically activate Rap1. Here, we generated RapGEF2 conditional knockout mice and studied its role in embryogenesis and fetal as well as adult hematopoietic stem cell (HSC) regulation. RapGEF2 deficiency led to embryonic letha...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
American Society of Hematology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2974602/ https://ncbi.nlm.nih.gov/pubmed/20595512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-262964 |
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