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Ligand-induced EGF Receptor Oligomerization Is Kinase-dependent and Enhances Internalization
The current activation model of the EGF receptor (EGFR) predicts that binding of EGF results in dimerization and oligomerization of the EGFR, leading to the allosteric activation of the intracellular tyrosine kinase. Little is known about the regulatory mechanism of receptor oligomerization. In this...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2998144/ https://ncbi.nlm.nih.gov/pubmed/20940297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.164731 |
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