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Two different neurodegenerative diseases caused by proteins with similar structures
The downstream prion-like protein (doppel, or Dpl) is a paralog of the cellular prion protein, PrP(C). The two proteins have ≈25% sequence identity, but seem to have distinct physiologic roles. Unlike PrP(C), Dpl does not support prion replication; instead, overexpression of Dpl in the brain seems t...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | en |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC30142/ https://ncbi.nlm.nih.gov/pubmed/11226243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051627998 |
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