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SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse
SIRT1 is a founding member of a sirtuin family of 7 proteins and histone deacetylases. It is involved in cellular resistance to stress, metabolism, differentiation, aging, and tumor suppression. SIRT1(−/−) mice demonstrate embryonic and postnatal development defects. We examined hematopoietic and en...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
American Society of Hematology
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3031475/ https://ncbi.nlm.nih.gov/pubmed/20966168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-273011 |
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