Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein

How dividing mammalian cells overcome blocks to DNA replication by DNA damage, depleted nucleotide pools, or template-bound proteins is unclear. Here, we show that the response to blocked replication requires BRCA2, a suppressor of human breast cancer. By using two-dimensional gel electrophoresis, w...

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Detalhes bibliográficos
Main Authors: Lomonosov, Mikhail, Anand, Shubha, Sangrithi, Mahesh, Davies, Rachel, Venkitaraman, Ashok R., Pera, Edgar M., Ikeda, Atsushi, Eivers, Edward, De Robertis, Eddy M., Cozzio, Antonio, Passegué, Emmanuelle, Ayton, Paul M., Karsunky, Holger, Cleary, Michael L., Weissman, Irving L., Wallén-Mackenzie, Åsa, Mata de Urquiza, Alexander, Petersson, Susanna, Rodriguez, Francisco J., Friling, Stina, Wagner, Joseph, Ordentlich, Peter, Lengqvist, Johan, Heyman, Richard A., Arenas, Ernest, Perlmann, Thomas, Dobreva, Gergana, Dambacher, Julia, Grosschedl, Rudolf, Jin, Jianping, Shirogane, Takahiro, Xu, Lai, Nalepa, Grzegorz, Qin, Jun, Elledge, Stephen J., Harper, J. Wade, Jin, Li, Guzik, Brian W., Bor, Yeou-cherng, Rekosh, David, Hammarskjöld, Marie-Louise, Tzahor, Eldad, Kempf, Hervé, Mootoosamy, Roy C., Poon, Andy C., Abzhanov, Arhat, Tabin, Clifford J., Dietrich, Susanne, Lassar, Andrew B., Karp, Xantha, Greenwald, Iva, Aguirre, Andrew J., Bardeesy, Nabeel, Sinha, Manisha, Lopez, Lyle, Tuveson, David A., Horner, James, Redston, Mark S., DePinho, Ronald A., Lewis, Brian C., Klimstra, David S., Varmus, Harold E., Joffe, Russell T., Wichers, Marieke C., Maes, Michael, Steiger, Howard, Lane, Carol J., Ngan, Elton T.C., Yatham, Lakshmi N., Ruth, Tom J., Liddle, Peter F., Leri, Francesco, Stewart, Jane, Tremblay, Annie, Bruneau, Julie, Honer, William G., Linseman, Mary Ann, Stavrakaki, Chrissoula, Antochi, Ruxandra, Emery, Patricia C., Parmar, Malvinder S., Baltzan, Marc, Thomas, Jennifer, Nevin, Robert D., Koren, Gideon, van Reekum, R., Juckes, Angus W., Ross, Ian B., Shaw, Neal H., Anderson, Stephen D., Cusimano, Michael D., Marchie, Anthony, Schabas, Richard E., Ovens, Howard J., Urszenyi, Stephen L., Hutcheon, David J., Burgess, Robert J., Verbeek, P. Richard, Schwartz, Brian, Greco, Dirceu B., Haddad, Henry, Hoey, John, Todkill, Anne Marie, Gagnon, Louise, Kent, Heather, Gandey, Allison, Ehman, Amy Jo, Mackay, Brad, Martin, Shelley
Formato: Artigo
Idioma:English
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Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Research Communications
Research Papers
Editorial
Review Paper
Research Paper
Brief Report
Reviewers
CCNP News and Views
Correction
Highlights of This Issue
Letters
Synopsis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC305253/
https://ncbi.nlm.nih.gov/pubmed/14681210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.279003
https://ncbi.nlm.nih.gov/pmc/articles/PMC305254/
https://ncbi.nlm.nih.gov/pubmed/14701872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1153603
https://ncbi.nlm.nih.gov/pmc/articles/PMC305255/
https://ncbi.nlm.nih.gov/pubmed/14701873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1143403
https://ncbi.nlm.nih.gov/pmc/articles/PMC305256/
https://ncbi.nlm.nih.gov/pubmed/14681209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.276003
https://ncbi.nlm.nih.gov/pmc/articles/PMC305257/
https://ncbi.nlm.nih.gov/pubmed/14701874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1153003
https://ncbi.nlm.nih.gov/pmc/articles/PMC305258/
https://ncbi.nlm.nih.gov/pubmed/14681206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1157503
https://ncbi.nlm.nih.gov/pmc/articles/PMC305259/
https://ncbi.nlm.nih.gov/pubmed/14701875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1155703
https://ncbi.nlm.nih.gov/pmc/articles/PMC305260/
https://ncbi.nlm.nih.gov/pubmed/14701876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1154103
https://ncbi.nlm.nih.gov/pmc/articles/PMC305261/
https://ncbi.nlm.nih.gov/pubmed/14701877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1160803
https://ncbi.nlm.nih.gov/pmc/articles/PMC305262/
https://ncbi.nlm.nih.gov/pubmed/14681207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1158703
https://ncbi.nlm.nih.gov/pmc/articles/PMC305263/
https://ncbi.nlm.nih.gov/pubmed/14681205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1140403
https://ncbi.nlm.nih.gov/pmc/articles/PMC305265/
https://ncbi.nlm.nih.gov/pubmed/14719045
https://ncbi.nlm.nih.gov/pmc/articles/PMC305266/
https://ncbi.nlm.nih.gov/pubmed/14719046
https://ncbi.nlm.nih.gov/pmc/articles/PMC305267/
https://ncbi.nlm.nih.gov/pubmed/14719047
https://ncbi.nlm.nih.gov/pmc/articles/PMC305268/
https://ncbi.nlm.nih.gov/pubmed/14719048
https://ncbi.nlm.nih.gov/pmc/articles/PMC305269/
https://ncbi.nlm.nih.gov/pubmed/14719049
https://ncbi.nlm.nih.gov/pmc/articles/PMC305270/
https://ncbi.nlm.nih.gov/pubmed/14719050
https://ncbi.nlm.nih.gov/pmc/articles/PMC305271/
https://ncbi.nlm.nih.gov/pubmed/14719051
https://ncbi.nlm.nih.gov/pmc/articles/PMC305272/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305273/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305274/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2235532100
https://ncbi.nlm.nih.gov/pmc/articles/PMC305275/
https://ncbi.nlm.nih.gov/pubmed/14707180
https://ncbi.nlm.nih.gov/pmc/articles/PMC305276/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305277/
https://ncbi.nlm.nih.gov/pubmed/14707184
https://ncbi.nlm.nih.gov/pmc/articles/PMC305278/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305279/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305280/
https://ncbi.nlm.nih.gov/pubmed/14707186
https://ncbi.nlm.nih.gov/pmc/articles/PMC305281/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305282/
https://ncbi.nlm.nih.gov/pubmed/14707187
https://ncbi.nlm.nih.gov/pmc/articles/PMC305283/
https://ncbi.nlm.nih.gov/pubmed/14707189
https://ncbi.nlm.nih.gov/pmc/articles/PMC305284/
https://ncbi.nlm.nih.gov/pubmed/14707191
https://ncbi.nlm.nih.gov/pmc/articles/PMC305285/
https://ncbi.nlm.nih.gov/pubmed/14707190
https://ncbi.nlm.nih.gov/pmc/articles/PMC305286/
https://ncbi.nlm.nih.gov/pubmed/14707193
https://ncbi.nlm.nih.gov/pmc/articles/PMC305287/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305288/
https://ncbi.nlm.nih.gov/pubmed/14707195
https://ncbi.nlm.nih.gov/pmc/articles/PMC305289/
https://ncbi.nlm.nih.gov/pubmed/14707194
https://ncbi.nlm.nih.gov/pmc/articles/PMC305290/
https://ncbi.nlm.nih.gov/pubmed/14707196
https://ncbi.nlm.nih.gov/pmc/articles/PMC305291/
https://ncbi.nlm.nih.gov/pubmed/14707197
https://ncbi.nlm.nih.gov/pmc/articles/PMC305292/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305293/
https://ncbi.nlm.nih.gov/pubmed/14707198
https://ncbi.nlm.nih.gov/pmc/articles/PMC305294/
https://ncbi.nlm.nih.gov/pubmed/14707201
https://ncbi.nlm.nih.gov/pmc/articles/PMC305295/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305297/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305298/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305299/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305300/
https://ncbi.nlm.nih.gov/pubmed/14707206
https://ncbi.nlm.nih.gov/pmc/articles/PMC305301/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305302/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305303/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305304/
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https://ncbi.nlm.nih.gov/pmc/articles/PMC305253/
https://ncbi.nlm.nih.gov/pubmed/14681210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.279003
https://ncbi.nlm.nih.gov/pmc/articles/PMC305254/
https://ncbi.nlm.nih.gov/pubmed/14701872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1153603
https://ncbi.nlm.nih.gov/pmc/articles/PMC305255/
https://ncbi.nlm.nih.gov/pubmed/14701873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1143403
https://ncbi.nlm.nih.gov/pmc/articles/PMC305256/
https://ncbi.nlm.nih.gov/pubmed/14681209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.276003
https://ncbi.nlm.nih.gov/pmc/articles/PMC305257/
https://ncbi.nlm.nih.gov/pubmed/14701874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1153003
https://ncbi.nlm.nih.gov/pmc/articles/PMC305258/
https://ncbi.nlm.nih.gov/pubmed/14681206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1157503
https://ncbi.nlm.nih.gov/pmc/articles/PMC305259/
https://ncbi.nlm.nih.gov/pubmed/14701875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1155703
https://ncbi.nlm.nih.gov/pmc/articles/PMC305260/
https://ncbi.nlm.nih.gov/pubmed/14701876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1154103
https://ncbi.nlm.nih.gov/pmc/articles/PMC305261/
https://ncbi.nlm.nih.gov/pubmed/14701877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1160803
https://ncbi.nlm.nih.gov/pmc/articles/PMC305262/
https://ncbi.nlm.nih.gov/pubmed/14681207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1158703
https://ncbi.nlm.nih.gov/pmc/articles/PMC305263/
https://ncbi.nlm.nih.gov/pubmed/14681205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1140403
https://ncbi.nlm.nih.gov/pmc/articles/PMC305265/
https://ncbi.nlm.nih.gov/pubmed/14719045
https://ncbi.nlm.nih.gov/pmc/articles/PMC305266/
https://ncbi.nlm.nih.gov/pubmed/14719046
https://ncbi.nlm.nih.gov/pmc/articles/PMC305267/
https://ncbi.nlm.nih.gov/pubmed/14719047
https://ncbi.nlm.nih.gov/pmc/articles/PMC305268/
https://ncbi.nlm.nih.gov/pubmed/14719048
https://ncbi.nlm.nih.gov/pmc/articles/PMC305269/
https://ncbi.nlm.nih.gov/pubmed/14719049
https://ncbi.nlm.nih.gov/pmc/articles/PMC305270/
https://ncbi.nlm.nih.gov/pubmed/14719050
https://ncbi.nlm.nih.gov/pmc/articles/PMC305271/
https://ncbi.nlm.nih.gov/pubmed/14719051
https://ncbi.nlm.nih.gov/pmc/articles/PMC305272/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305273/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305274/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2235532100
https://ncbi.nlm.nih.gov/pmc/articles/PMC305275/
https://ncbi.nlm.nih.gov/pubmed/14707180
https://ncbi.nlm.nih.gov/pmc/articles/PMC305276/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305277/
https://ncbi.nlm.nih.gov/pubmed/14707184
https://ncbi.nlm.nih.gov/pmc/articles/PMC305278/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305279/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305280/
https://ncbi.nlm.nih.gov/pubmed/14707186
https://ncbi.nlm.nih.gov/pmc/articles/PMC305281/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305282/
https://ncbi.nlm.nih.gov/pubmed/14707187
https://ncbi.nlm.nih.gov/pmc/articles/PMC305283/
https://ncbi.nlm.nih.gov/pubmed/14707189
https://ncbi.nlm.nih.gov/pmc/articles/PMC305284/
https://ncbi.nlm.nih.gov/pubmed/14707191
https://ncbi.nlm.nih.gov/pmc/articles/PMC305285/
https://ncbi.nlm.nih.gov/pubmed/14707190
https://ncbi.nlm.nih.gov/pmc/articles/PMC305286/
https://ncbi.nlm.nih.gov/pubmed/14707193
https://ncbi.nlm.nih.gov/pmc/articles/PMC305287/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305288/
https://ncbi.nlm.nih.gov/pubmed/14707195
https://ncbi.nlm.nih.gov/pmc/articles/PMC305289/
https://ncbi.nlm.nih.gov/pubmed/14707194
https://ncbi.nlm.nih.gov/pmc/articles/PMC305290/
https://ncbi.nlm.nih.gov/pubmed/14707196
https://ncbi.nlm.nih.gov/pmc/articles/PMC305291/
https://ncbi.nlm.nih.gov/pubmed/14707197
https://ncbi.nlm.nih.gov/pmc/articles/PMC305292/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305293/
https://ncbi.nlm.nih.gov/pubmed/14707198
https://ncbi.nlm.nih.gov/pmc/articles/PMC305294/
https://ncbi.nlm.nih.gov/pubmed/14707201
https://ncbi.nlm.nih.gov/pmc/articles/PMC305295/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305297/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305298/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305299/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305300/
https://ncbi.nlm.nih.gov/pubmed/14707206
https://ncbi.nlm.nih.gov/pmc/articles/PMC305301/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305302/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305303/
https://ncbi.nlm.nih.gov/pmc/articles/PMC305304/

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