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Transforming Growth Factor-β1 Mediates Epithelial to Mesenchymal Transdifferentiation through a RhoA-dependent Mechanism

Transforming growth factor-β1 (TGF-β) can be tumor suppressive, but it can also enhance tumor progression by stimulating the complex process of epithelial-to-mesenchymal transdifferentiaion (EMT). The signaling pathway(s) that regulate EMT in response to TGF-β are not well understood. We demonstrate...

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Detalhes bibliográficos
Main Authors: Bhowmick, Neil A., Ghiassi, Mayshan, Bakin, Andrei, Aakre, Mary, Lundquist, Christopher A., Engel, Michael E., Arteaga, Carlos L., Moses, Harold L.
Formato: Artigo
Idioma:en
Publicado em: The American Society for Cell Biology 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC30565/
https://ncbi.nlm.nih.gov/pubmed/11160820
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