An unliganded thyroid hormone receptor causes severe neurological dysfunction

Congenital hypothyroidism and the thyroid hormone (T(3)) resistance syndrome are associated with severe central nervous system (CNS) dysfunction. Because thyroid hormones are thought to act principally by binding to their nuclear receptors (TRs), it is unexplained why TR knock-out animals are report...

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Autors principals: Hashimoto, Koshi, Curty, Flavio H., Borges, Patricia P., Lee, Charlotte E., Abel, E. Dale, Elmquist, Joel K., Cohen, Ronald N., Wondisford, Fredric E.
Format: Article
Idioma:en
Publicat: The National Academy of Sciences 2001
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC31168/
https://ncbi.nlm.nih.gov/pubmed/11274423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051454698
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https://ncbi.nlm.nih.gov/pmc/articles/PMC31168/
https://ncbi.nlm.nih.gov/pubmed/11274423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051454698

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