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Sequence-dependent cleavage of DNA by alkylation with antisense oligodeoxyribonucleotides containing a 2-(N-iodoacetylaminoethyl)thio-adenine.
Antisense oligodeoxyribonucleotides (15mers), containing a 2-(N-iodoacetylaminoethyl)thio-adenine, were synthesized and tested for their ability to cleave complementary DNAs (21mers). Cleavage of the target DNAs was done by alkylation followed by treatment with piperidine, and the positions of the a...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | en |
| Publicado em: |
1992
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC312180/ https://ncbi.nlm.nih.gov/pubmed/1561091 |
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