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Substrate specificity and mutational analysis of Kluyveromyces lactis γ-toxin, a eukaryal tRNA anticodon nuclease

tRNA anticodon damage inflicted by the Kluyveromyces lactis γ-toxin underlies an RNA-based innate immune system that distinguishes self from nonself species. γ-toxin arrests the growth of Saccharomyces cerevisiae by incising a single phosphodiester 3′ of the wobble base of tRNA(Glu(UUC)) to generate...

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Detalhes bibliográficos
Formato: Artigo
Idioma:en
Publicado em: Cold Spring Harbor Laboratory Press 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138569/
https://ncbi.nlm.nih.gov/pubmed/21610213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2722711
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