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Design and characterization of N2-arylaminopurines which selectively inhibit replicative DNA synthesis and replication-specific DNA polymerases: guanine derivatives active on mammalian DNA polymerase alpha and bacterial DNA polymerase III.
The 2-amino substituted derivatives of guanine, N2-(p-n-butylphenyl)guanine (BuPG) and N2-(3',4'-trimethylenephenyl) guanine (TMPG), were synthesized and found to selectively inhibit, respectively, HeLa cell DNA polymerase alpha (po1 alpha) and B. subtilis DNA polymerase III (po1 III). Bot...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | en |
| Publicado em: |
1982
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC320811/ https://ncbi.nlm.nih.gov/pubmed/6812026 |
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