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Is the bithiazole moiety of bleomycin a classical intercalator?
Bleomycin is a widespread anticancerous drug, the biological activity of which having been extensively studied. Its metal ion-chelating portion has been shown to cleave DNA whereas the role of the bithiazole moiety is still questionable. In order to elucidate this problem some 2', 4-disubstitut...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | en |
| Publicado em: |
1985
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC321987/ https://ncbi.nlm.nih.gov/pubmed/2414728 |
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