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The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression
For the past five years, evidence has accumulated that vector-mediated robust RNA interference (RNAi) expression can trigger severe side effects in small and large animals, from cytotoxicity and accelerated tumorigenesis to organ failure and death. The recurring notions in these studies that a criti...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
BioMed Central
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3234190/ https://ncbi.nlm.nih.gov/pubmed/22029761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1758-907X-2-8 |
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