p66SHC Promotes Apoptosis and Antagonizes Mitogenic Signaling in T Cells

Of the three Shc isoforms, p66Shc is responsible for fine-tuning p52/p46Shc signaling to Ras and has been implicated in apoptotic responses to oxidative stress. Here we show that human peripheral blood lymphocytes and mouse thymocytes and splenic T cells acquire the capacity to express p66Shc in res...

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Detalhes bibliográficos
Main Authors: Pacini, Sonia, Pellegrini, Michela, Migliaccio, Enrica, Patrussi, Laura, Ulivieri, Cristina, Ventura, Andrea, Carraro, Fabio, Naldini, Antonella, Lanfrancone, Luisa, Pelicci, Piergiuseppe, Baldari, Cosima T.
Formato: Artigo
Idioma:en
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC344195/
https://ncbi.nlm.nih.gov/pubmed/14749389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.4.1747-1757.2004
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Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC344195/
https://ncbi.nlm.nih.gov/pubmed/14749389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.4.1747-1757.2004

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