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Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism

The Ser/Thr kinase Raf-1 is a protooncogene product that is a central component in many signaling pathways involved in normal cell growth and oncogenic transformation. Upon activation, Raf-1 phosphorylates mitogen-activated protein kinase kinase (MEK), which in turn activates mitogen-activated prote...

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Detalhes bibliográficos
Main Authors: Chen, Jing, Fujii, Katsunori, Zhang, Lixin, Roberts, Thomas, Fu, Haian
Formato: Artigo
Idioma:en
Publicado em: The National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC35419/
https://ncbi.nlm.nih.gov/pubmed/11427728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.141224398
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