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RNF4 is required for DNA double-strand break repair in vivo
Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signaling and repair proteins to the sites of DNA lesions. Coordinated protein SUMOylation and ubiquitylation have crucial...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3569989/ https://ncbi.nlm.nih.gov/pubmed/23197296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.145 |
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