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Combining different design strategies for rational affinity maturation of the MICA-NKG2D interface
We redesigned residues on the surface of MICA, a protein that binds the homodimeric immunoreceptor NKG2D, to increase binding affinity with a series of rational, incremental changes. A fixed-backbone RosettaDesign protocol scored a set of initial mutations, which we tested by surface plasmon resonan...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
Wiley Subscription Services, Inc., A Wiley Company
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3631368/ https://ncbi.nlm.nih.gov/pubmed/22761154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2115 |
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