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Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site

BACKGROUND: Glutaminyl cyclase (QC) forms the pyroglutamyl residue at the amino terminus of numerous secretory peptides and proteins. We previously proposed the mammalian QC has some features in common with zinc aminopeptidases. We now have generated a structural model for human QC based on the amin...

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Main Authors: Booth, Rachell E, Lovell, Simon C, Misquitta, Stephanie A, Bateman, Robert C
格式: Artigo
語言:en
出版: BioMed Central 2004
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC368447/
https://ncbi.nlm.nih.gov/pubmed/15028118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-2-2
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