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Telomeric DNA damage is irreparable and causes persistent DNA damage response activation
The DNA damage response (DDR) arrests cell-cycle progression until damage is removed. DNA damage-induced cellular senescence is associated with persistent DDR. The molecular bases that distinguish transient from persistent DDR are unknown. Here we show that a large fraction of exogenously-induced pe...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3717580/ https://ncbi.nlm.nih.gov/pubmed/22426077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2466 |
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