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Medullary thymic epithelial cell depletion leads to autoimmune hepatitis
TRAF6, an E3 ubiquitin protein ligase, plays a critical role in T cell tolerance by regulating medullary thymic epithelial cell (mTEC) development. mTECs regulate T cell tolerance by ectopically expressing self-antigens and eliminating autoreactive T cells in the thymus. Here we show that mice with...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
American Society for Clinical Investigation
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3726151/ https://ncbi.nlm.nih.gov/pubmed/23867620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65414 |
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