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Estrogen receptor α can selectively repress dioxin receptor-mediated gene expression by targeting DNA methylation
Selective inhibitory crosstalk has been known to occur within the signaling pathways of the dioxin (AhR) and estrogen (ERα) receptors. More specifically, ERα represses a cytochrome P450-encoding gene (CYP1A1) that converts cellular estradiol into a metabolite that inhibits the cell cycle, while it h...
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| Formato: | Artigo |
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| Idioma: | en |
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Oxford University Press
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3783176/ https://ncbi.nlm.nih.gov/pubmed/23828038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt595 |
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