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Inhibition of human gamma-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors
Gamma-glutamyl transpeptidase (GGT) is an essential enzyme for maintaining cysteine homeostasis, leukotriene synthesis, metabolism of glutathione-conjugates and catabolism of extracellular glutathione. Overexpression of GGT has been implicated in many pathologies, and clinical inhibitors of GGT are...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3836663/ https://ncbi.nlm.nih.gov/pubmed/23301618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20121435 |
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