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Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists.

Full activation of T cells requires signaling through the T-cell antigen receptor (TCR) and additional surface molecules interacting with ligands on the antigen-presenting cell. TCR recognition of agonist ligands in the absence of accessory signals frequently results in the induction of a state of u...

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Detalhes bibliográficos
Main Authors: Madrenas, J, Schwartz, R H, Germain, R N
Formato: Artigo
Idioma:en
Publicado em: 1996
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC38498/
https://ncbi.nlm.nih.gov/pubmed/8790400
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