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T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions
αβ T-cell receptors (TCRs) engage antigens using complementarity-determining region (CDR) loops that are either germ line-encoded (CDR1 and CDR2) or somatically rearranged (CDR3). TCR ligands compose a presentation platform (major histocompatibility complex (MHC)) and a variable antigenic component...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3887192/ https://ncbi.nlm.nih.gov/pubmed/24196962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.522110 |
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