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A synthetic Toll-like receptor 3 ligand mitigates profibrotic fibroblast responses by inducing autocrine interferon signaling

Activation of Toll-like receptor-3 (TLR3) by exogenous microbial ligands or endogenous injury-associated ligands leads to production of type I interferon (IFN). Scleroderma patients with progressive skin fibrosis display an IFN-regulated gene signature, implicating TLR3 signaling in the disease. We...

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Formato: Artigo
Idioma:en
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924580/
https://ncbi.nlm.nih.gov/pubmed/23956427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300376
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