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A synthetic Toll-like receptor 3 ligand mitigates profibrotic fibroblast responses by inducing autocrine interferon signaling
Activation of Toll-like receptor-3 (TLR3) by exogenous microbial ligands or endogenous injury-associated ligands leads to production of type I interferon (IFN). Scleroderma patients with progressive skin fibrosis display an IFN-regulated gene signature, implicating TLR3 signaling in the disease. We...
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| Format: | Article |
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| Idioma: | en |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3924580/ https://ncbi.nlm.nih.gov/pubmed/23956427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300376 |
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