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Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression
Priapism is featured with prolonged and painful penile erection and is prevalent among males with sickle cell disease (SCD). The disorder is a dangerous urological and hematological emergency since it is associated with ischemic tissue damage and erectile disability. Here we report that phosphodiest...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
Federation of American Societies for Experimental Biology
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4021439/ https://ncbi.nlm.nih.gov/pubmed/24614760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-247833 |
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