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Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice
Restriction factors (RFs) form important components of host defenses to retroviral infection. The Fv1, Trim5α, and TrimCyp RFs contain N-terminal dimerization and C-terminal specificity domains that target assembled retroviral capsid (CA) proteins enclosing the viral core. However, the molecular det...
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| Formato: | Artigo |
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| Idioma: | en |
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National Academy of Sciences
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4084454/ https://ncbi.nlm.nih.gov/pubmed/24979782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402448111 |
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