Hepatic and glucagon-like peptide-1–mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors

Uncontrolled hepatic glucose production contributes significantly to hyperglycemia in patients with type 2 diabetes. Hyperglucagonemia is implicated in the etiology of this condition; however, effective therapies to block glucagon signaling and thereby regulate glucose metabolism do not exist. To de...

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Main Authors: Sloop, Kyle W., Cao, Julia Xiao-Chun, Siesky, Angela M., Zhang, Hong Yan, Bodenmiller, Diane M., Cox, Amy L., Jacobs, Steven J., Moyers, Julie S., Owens, Rebecca A., Showalter, Aaron D., Brenner, Martin B., Raap, Achim, Gromada, Jesper, Berridge, Brian R., Monteith, David K. B., Porksen, Niels, McKay, Robert A., Monia, Brett P., Bhanot, Sanjay, Watts, Lynnetta M., Michael, M. Dodson
Formato: Artigo
Idioma:en
Publicado em: American Society for Clinical Investigation 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC419489/
https://ncbi.nlm.nih.gov/pubmed/15173883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420911
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https://ncbi.nlm.nih.gov/pmc/articles/PMC419489/
https://ncbi.nlm.nih.gov/pubmed/15173883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420911

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