Akt Mediates Ras Downregulation of RhoB, a Suppressor of Transformation, Invasion, and Metastasis

Although recent evidence supports a tumor-suppressive role for the GTPase RhoB, little is known about its regulation by signal transduction pathways. Here we demonstrate that Ras downregulates RhoB expression by a phosphatidylinositol 3-kinase (PI3K)- and Akt- but not Mek-dependent mechanism. Furthe...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Jiang, Kun, Sun, Jiazhi, Cheng, Jin, Djeu, Julie Y., Wei, Sheng, Sebti, Saïd
Формат: Статья
Язык:en
Опубликовано: American Society for Microbiology 2004
Предметы:
Cell Growth and Development
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC419878/
https://ncbi.nlm.nih.gov/pubmed/15169915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.12.5565-5576.2004
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC419878/
https://ncbi.nlm.nih.gov/pubmed/15169915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.12.5565-5576.2004

Схожие документы