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Polyglutamine- and Temperature-Dependent Conformational Rigidity in Mutant Huntingtin Revealed by Immunoassays and Circular Dichroism Spectroscopy
BACKGROUND: In Huntington's disease, expansion of a CAG triplet repeat occurs in exon 1 of the huntingtin gene (HTT), resulting in a protein bearing>35 polyglutamine residues whose N-terminal fragments display a high propensity to misfold and aggregate. Recent data demonstrate that polygluta...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
Public Library of Science
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4251833/ https://ncbi.nlm.nih.gov/pubmed/25464275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112262 |
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