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Integration of G Protein α (Gα) Signaling by the Regulator of G Protein Signaling 14 (RGS14)
RGS14 contains distinct binding sites for both active (GTP-bound) and inactive (GDP-bound) forms of Gα subunits. The N-terminal regulator of G protein signaling (RGS) domain binds active Gα(i/o)-GTP, whereas the C-terminal G protein regulatory (GPR) motif binds inactive Gα(i1/3)-GDP. The molecular b...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2015
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4423691/ https://ncbi.nlm.nih.gov/pubmed/25666614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.634329 |
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