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Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping
Induction of fetal hemoglobin (HbF) production in adult erythrocytes can reduce the severity of sickle cell disease and β-thalassemia. Transcription of β-globin genes is regulated by the distant locus control region (LCR), which is brought into direct gene contact by the LDB1/GATA-1/TAL1/LMO2-contai...
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| Формат: | Статья |
|---|---|
| Язык: | en |
| Опубликовано: |
American Society of Hematology
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4520881/ https://ncbi.nlm.nih.gov/pubmed/25979948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-02-629972 |
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