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ADAMTS13 and von Willebrand Factor in Thrombotic Thrombocytopenic Purpura
Pathogenesis of thrombotic thrombocytopenic purpura (TTP) was a mystery for over half a century until the discovery of ADAMTS13. ADAMTS13 is primarily synthesized in the liver, and its main function is to cleave von Willebrand factor (VWF) anchored on the endothelial surface, in circulation, and at...
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| Formato: | Artigo |
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| Idioma: | en |
| Publicado em: |
2015
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4599565/ https://ncbi.nlm.nih.gov/pubmed/25587650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-med-061813-013241 |
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